STAT+: Small studies offer hope CAR-T can fight an aggressive brain cancer
Several studies found that CAR-T therapy shrank tumors in glioblastoma multiforme, offering hope of a potential new weapon against a common, intransigent cancer.
A series of new studies are raising hopes that CAR-T, a process in which treatments are made by genetically editing a patient’s own white blood cells, can eventually be used to treat an incurable and deadly type of brain cancer, called glioblastoma multiforme, or GBM.
In the most dramatic result, from a three-person study conducted by researchers at Massachusetts General Hospital, a 72-year-old man saw his tumor shrink 18.5% in just two days and then decrease further over the next two months until it was 60% smaller than when treatment began. That’s notable because glioblastoma is a cancer where drugs can normally only prevent a tumor from growing. Researchers say the results, published in the New England Journal of Medicine on Wednesday, do not mean the treatment is ready to be used widely but give reason to think they are on the right track.
“We have seen some shrinking of tumors, but not this dramatic and not this fast,” said Behnam Badie, a neurosurgeon at City of Hope who has conducted CAR-T trials in brain tumor patients and was not involved in the study.
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