Spontaneous transfer of mitochondrial DNA into the nuclear genomes in the human brain over the individual’s lifespan
Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and accumulate in brain tissues during development or over the human lifespan. Credit: Lior Kirsch, 2016, PLOS Computational Biology, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) Somatic nuclear mitochondrial DNA (Numt) […]
Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and accumulate in brain tissues during development or over the human lifespan.
Credit: Lior Kirsch, 2016, PLOS Computational Biology, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and accumulate in brain tissues during development or over the human lifespan.
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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002723
Article Title: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
Author Countries: United States
Funding: see manuscript
Journal
PLoS Biology
DOI
10.1371/journal.pbio.3002723
Method of Research
Observational study
Subject of Research
Cells
COI Statement
Competing interests: The authors have declared that no competing interests exist.
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