Rewrite Platform rapidly designs organ-scale vasculature trees for 3D bioprinting this news headline for the science magazine post

Zachary Sexton and colleagues have developed a design platform that can rapidly generate vasculature trees that can then be bioprinted and used to successfully perfuse living tissue constructs. The platform improves the design and production of complex vascular networks that will be needed for manufacturing human tissues and organs in the future. As the researchers note, the manufacture of tissues with multiple cell types has improved recently. But like a city needs a full complement of main highways, side streets, and alleyways to carry traffic its furthest reaches, complex geometric tissues and organs need a vasculature network that will reach and adequately perfuse blood throughout the tissue – a design feat that has remained challenging for researchers. Sexton et al. leveraged algorithmic advances to create a synthetic toolkit that can generate organ-spanning tree networks within minutes (a 230-fold acceleration over current platform speeds), with the ability to simulate flow patterns and pressures. The researchers created computational vasculature networks for more than 200 engineered and anatomical models. In a bioreactor, the researchers also tested the perfusion of 3D bioprinted networks, which improved the cell viability of the printed tissue constructs.

Journal

Science

DOI

10.1126/science.adj6152

Article Title

Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing

Article Publication Date

12-Jun-2025

Media Contact

Science Press Package Team

American Association for the Advancement of Science/AAAS

scipak@aaas.org

Journal

Science

DOI

10.1126/science.adj6152

Article Title

Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing

.adsslot_AqwpYDsth8{width:728px !important;height:90px !important;}
@media(max-width:1199px){ .adsslot_AqwpYDsth8{width:468px !important;height:60px !important;}
}
@media(max-width:767px){ .adsslot_AqwpYDsth8{width:320px !important;height:50px !important;}
}

ADVERTISEMENT Article Publication Date

12-Jun-2025

bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
Subject of Research:
Article Title:
News Publication Date:
Web References:
References:
Image Credits:

Keywords
Tags: 3D bioprinting vasculature networksadvancements in multi-cell type tissue productionalgorithmic advances in bioprintingbioreactor testing for tissue constructscomplex vascular networks in tissue engineeringcomputational modeling of vascular systemsenhancing cell viability in bioprinted tissuesgeometric design challenges in tissue engineeringmanufacturing human tissues and organsperfusion of living tissue constructsrapid organ-scale design platformsynthetic toolkit for vascular design