Rewrite Modular alkyl growth in amines via the selective insertion of alkynes into C–C bonds as a headline for a science magazine post, using no more than 8 words

The site-specific modification of amines has been a highly sought-after objective in organic synthesis. Despite the rapid advancement of carbon–hydrogen (C–H) bond functionalization methods, effective strategies for carbon–carbon (C–C) bond functionalization of amines remain elusive. Here we report a borane-catalysed method for the selective insertion of alkynes into alkyl C–C bonds of amines, resulting in the ring expansion of cyclic amines and chain elongation of acyclic amines. This approach begins with the cleavage of C–H bonds in amines, then transitioning to C–C bond functionalization upon reaction with alkynes. This method is effective with amines lacking an activating or leaving group and is suitable for late-stage functionalization of pharmaceuticals through C–C bond modification. Furthermore, by coupling this reaction with hydrolysis and hydrogenation steps, successive alkyne insertions are achieved, enabling modular and iterative alkyl growth of amines.

Zhou, XY., Liu, L., Lyu, H. et al. Modular alkyl growth in amines via the selective insertion of alkynes into C–C bonds.
Nat. Chem. (2025).

.adsslot_lmB28Snip9{ width:728px !important; height:90px !important; }
@media (max-width:1199px) { .adsslot_lmB28Snip9{ width:468px !important; height:60px !important; } }
@media (max-width:767px) { .adsslot_lmB28Snip9{ width:320px !important; height:50px !important; } }

ADVERTISEMENT

bu içeriği en az 2500 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 14 paragraf ve her bir paragrafta da en az 80 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:

Subject of Research:

Article Title:

Article References:

Zhou, XY., Liu, L., Lyu, H. et al. Modular alkyl growth in amines via the selective insertion of alkynes into C–C bonds.
Nat. Chem. (2025). https://doi.org/10.1038/s41557-025-01849-1

Image Credits: AI Generated

DOI:

Keywords:

Tags: advancements in organic chemistry methodsalkyne insertions in aminesborane-catalyzed reactionsC-C bond functionalization methodscarbon-hydrogen bond functionalizationchain elongation of acyclic aminesiterative alkyl growth techniqueslate-stage functionalization of pharmaceuticalsmodular alkyl growth in organic synthesisring expansion of cyclic aminesselective insertion of alkynessite-specific modification of amines