Rewrite Brain implantation of soft bioelectronics via embryonic development as a headline for a science magazine post, using no more than 7 words

Developing bioelectronics capable of stably tracking brain-wide, single-cell, millisecond-resolved neural activity in the developing brain is critical for advancing neuroscience and understanding neurodevelopmental disorders. During development, the three-dimensional structure of the vertebrate brain arises from a two-dimensional neural plate1,2. These large morphological changes have previously posed a challenge for implantable bioelectronics to reliably track neural activity throughout brain development3,4,5,6,7,8,9. Here we introduce a tissue-level-soft, submicrometre-thick mesh microelectrode array that integrates into the embryonic neural plate by leveraging the tissue’s natural two-dimensional-to-three-dimensional reconfiguration. As organogenesis progresses, the mesh deforms, stretches and distributes throughout the brain, seamlessly integrating with neural tissue. Immunostaining, gene expression analysis and behavioural testing confirm no adverse effects on brain development or function. This embedded electrode array enables long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development. In axolotl models, it not only records neural electrical activity during regeneration but also modulates the process through electrical stimulation.

Sheng, H., Liu, R., Li, Q. et al. Brain implantation of soft bioelectronics via embryonic development.
Nature (2025).

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bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:

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Sheng, H., Liu, R., Li, Q. et al. Brain implantation of soft bioelectronics via embryonic development.
Nature (2025). https://doi.org/10.1038/s41586-025-09106-8

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Tags: axolotl neural regeneration researchbioelectronics for neural activity trackingbrain function and development correlationelectrical stimulation in neural developmentembryonic brain development researchinnovative neuroscience methodologieslong-term neural monitoring technologiesneurodevelopmental disorder studiessingle-cell neural activity mappingsoft implantable microelectrode arraysthree-dimensional neural plate integrationtissue-engineered bioelectronics