Pneumagen raises £8 million for further study of intranasal antiviral
The Scottish company raised further funding to fuel an upcoming Phase IIb study of its compound neumifil in COPD patients.
Pneumagen has raised £8m ($10 million) for the further development of its intranasal antiviral drug neumifil in Phase II studies for chronic obstructive pulmonary disease (COPD) patients suffering from virus-induced exacerbations.
A Phase IIb study of neumifil is currently planned to start in 2024, per the 1 June announcement. According to the company’s website, the Phase IIb is planned to begin in early 2024.
The St. Andrews, UK-based company raised the funds from the venture investment company Esperante Ventures, alongside existing investors Thairm Bio and Scottish Enterprise. Pneumagen is originally a spinout from the Scottish University of St. Andrews.
Neumifil consists of an engineered carbohydrate-binding module domain of a Streptococcus pneumoniae protein. The vaccine is self-administered through an intranasal spray, and is based on the company’s GlycoTarge platform. The platform is derived from bacterial glycosidases and is researched for potential prophylactic use against respiratory viruses such as influenza. It can also be explored for other viruses like respiratory syncytial virus, human rhino virus and coronaviruses.
Additionally, the company expects to share initial results from the ongoing Phase IIa (NCT05507567) proof-of-concept challenge study in healthy subjects infected with influenza in mid-2023. The company dosed the first patient for this study in August 2022. The company had previously raised raised £3.8 million ($4.75 million) for the Phase II development of neumifil in January 2022.
In May 2022, Pneumagen shared positive topline data from a 60-participant Phase I study (NCT05093530). Neumifil was reported to be well tolerated with no dose-limiting toxicities and no serious adverse events.
The Scottish company previously studied neumifil and other multivalent carbohydrate binding modules against Covid-19. In April 2020, Pneumagen announced positive anti-viral activity results from three in vitro studies into preventing coronavirus infections, but the program has not yet been studied in humans.
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