PB-357 by Puma Biotechnology for Breast Cancer: Likelihood of Approval

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

PB-357 overview

PB-357 is under development for the treatment of breast cancer. The drug candidate is administered through oral route. It is as a backup compound to PB272 and is structurally similar to neratinib (PB-272). PB-357 is an irreversible tyrosine kinase inhibitor. It acts by targeting HER1, HER2 and HER4.

Puma Biotechnology overview

Puma Biotechnology (Puma) is a biopharmaceutical company that develops novel therapeutics for the treatment of cancer. The company develops and commercializes drug candidates, namely, PB272 (neratinib, oral), PB272 (neratinib, intravenous) and PB357. The company’s pipeline portfolio also encompasses investigational candidates for various indications such as adjuvant breast cancer, gastric cancer, metastatic breast cancer and HER2-positive breast cancer and other cancers. Puma in-licenses its drug candidates and advances its development through clinical testing and for commercial use. Puma manufacture and distribute its products through the third party contractors. Puma is headquartered in Los Angeles, California, the US.

For a complete picture of PB-357’s drug-specific PTSR and LoA scores, buy the report here.