New Research Reveals Underdiagnosis and Undertreatment of Peripheral Artery Disease, Highlighting Key Opportunities for Enhanced Care and Reduced Mortality

In a significant revelation from a recent Intermountain Health study presented at the American College of Cardiology’s annual scientific sessions in Chicago, researchers have illuminated the alarming prevalence of peripheral artery disease (PAD) in the American populace. This condition, which affects over 10 million individuals aged over 40, is frequently underdiagnosed and inadequately treated, leading to devastating health outcomes. The staggering mortality rate associated with PAD is especially pronounced among those who are unaware of their condition, particularly women, who receive less guideline-directed medical therapy compared to men.

Peripheral artery disease occurs when the arteries that supply blood to the limbs become narrowed or blocked due to a buildup of fatty deposits, known as plaque. This condition results in reduced blood flow, which can lead to a number of severe health consequences, including limb pain, ulcers, and critical limb ischemia. Although PAD can be asymptomatic in some individuals, it often manifests through symptoms such as leg pain during physical activity, coldness in the feet, and non-healing wounds. As PAD progresses, the risk of vascular events, like heart attacks or strokes, escalates significantly, which is alarming given the study’s findings indicating that patients with PAD have a more than 50 percent chance of dying due to the disease.

Viet T. Le, DMSc, MPAS, PA-C, the primary investigator of the study, emphasizes the urgent need for improved screening and treatment protocols for PAD, especially among women. The disparity in treatment between genders is troubling; while the study showed that only 29.6 percent of women and 33.5 percent of men received optimal guideline-directed care—comprising antiplatelet agents and statins—the concerning aspect lies in the fact that women were found to be less likely than men to attain adequate management of their disease despite having similar referral rates to specialists.

In the context of the research, a thorough examination of 7,522 symptomatic PAD patients treated at Intermountain Health from January 2006 to December 2021 yielded impactful insights. Of that cohort, 38 percent were women and 62 percent were men. The analysis highlighted a drastic under-treatment of these patients, which is compounded by the existing challenges that healthcare providers face in diagnosing and treating PAD effectively. The vague presentation of symptoms often leads to misdiagnosis or a lack of urgency in evaluation, as many clinicians may not recognize the critical nature of PAD or may prioritize other cardiovascular conditions.

Le points out that the treatment landscape for PAD is complicated by the fact that symptoms can be misattributed to various other health concerns, creating a barrier to timely and effective care. Additionally, the lack of awareness around the specificities of PAD treatment among healthcare professionals can exacerbate the low treatment rates. Cardiologists, for instance, may primarily focus on the management of heart disease, potentially overlooking the distinct needs of patients suffering from PAD.

This study serves as a wake-up call for health systems across the nation, advocating for enhanced methods that not only identify patients at risk but also ensure comprehensive care options are available. The high mortality rate associated with untreated PAD illustrates the dire need for intervention and the implementation of effective treatment pathways geared towards the specific needs of patients. As the research indicates, every individual diagnosed with PAD should be receiving elemental therapies like antiplatelet medications and statins to mitigate their risk of severe cardiovascular events.

Despite the grim statistics surrounding PAD, there are avenues for intervention. While the disease itself cannot be cured, appropriate lifestyle modifications, including a healthier diet and increased physical activity, along with medical therapies and surgical options, can significantly improve patients’ quality of life and slow the progression of the disease. Increased awareness and strategic partnerships among healthcare providers can lead to more coordinated care efforts, which is essential in addressing the unique challenges posed by PAD.

The findings of this study serve to reinforce the importance of vigilance and education within the medical community regarding peripheral artery disease. With the occurrence of PAD increasingly capturing attention, it is vital that healthcare providers remain cognizant of the condition’s presentation and take proactive measures to screen at-risk populations. Women, in particular, require focused care strategies that address the treatment gaps identified in this research.

Ultimately, the call to action delineated by Le and his colleagues is clear: a systematic overhaul of how PAD is approached in clinical settings is needed to lower the alarming death rates associated with the condition. Enhanced screening practices and a commitment to individualized patient care will go a long way toward safeguarding the health and wellbeing of individuals at risk of PAD. The collective response from healthcare organizations, clinicians, and policymakers will be instrumental in reversing the trend of underdiagnosis and under-treatment that currently plagues patients with this debilitating disease.

Significantly, the discourse initiated by this study extends beyond the realm of individual patient care; it encompasses a broader narrative about the implications of cardiovascular health among populations, especially as they relate to gender disparities. Enhanced research, public health initiatives, and an emphasis on education within the medical field will be pivotal in championing better health outcomes for individuals grappling with the challenges of peripheral artery disease. The time to act is now.

Research findings like those from the Intermountain Health study constitute a vital contribution to the ongoing discourse surrounding cardiovascular diseases while underscoring the urgent need for medical professionals to step up in the fight against PAD. This represents not just a health challenge, but a collective call for improvement and innovation in patient care practices.

In conclusion, peripheral artery disease represents a significant public health issue that requires immediate attention and action at all levels of healthcare. The insights gleaned from the Intermountain Health study compel the clinical community to prioritize screening, treatment, and ongoing education to fundamentally change the trajectory of care for millions of affected individuals and ultimately reduce the unacceptable mortality rate associated with this condition.

Subject of Research: Peripheral Artery Disease
Article Title: Alarming Findings on Peripheral Artery Disease: Underdiagnosis and High Mortality Rates
News Publication Date: March 30, 2025
Web References: N/A
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Image Credits: Intermountain Health

Keywords: Peripheral artery disease, cardiovascular health, underdiagnosis, mortality, gender disparities, clinical care

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